RESEARCH

Taking personalized medicine
from the lab to the real world.

Core Technology

Organoids are self-organizing 3D miniature organs derived from stem cells. The organoid culture technique, unlike prior 2D culture techniques, allows observations of micro-anatomy closely resembling the inner body environment. Attis Lab has successfully developed organoid culture methods for the following stem and cancer cell categories.

Stem cell
Cancer cell

[ Stem Cell 3D Organoid ]

Successful organoid culture of hair follicle stem cells, liver stem cells, lung stem cells, and pancreatic stem cells.


Stem cell culture technology

We succeeded in the mass production of stem cells using 3D organoid culture technology. Utilizing this feat, we are currently in the process of developing personalized cell therapy using various types of stem cells.

[ Cancer Cell 3D Organoid ]

Successful organoid culture of lung cancer, gallbladder cancer, and stomach cancer cells.


Cancer cell culture technology

We culture various types of cancer cells using the 3D organoid culture technique to use for drug screening and modeling of the cancer organ.

Our Applications

The organoid culture platform has various applications as it can accurately recreate the inner body environment. Based on successful and efficient organoid culture techniques, Attis Lab has developed the following applications.

Cancer Organ
Drug Screening
Cell Therapy

[ Clone Cancer Organ ]

The high similarity of clone cancer organs and actual organs allows for the direct observation of anticancer drug effects.


Culture and Transplantation

Production of cancer clone organs through the culture and injection of cancer cells cultured using 3D organoids.

Disease Model

Cancer clone organs can be used as a disease model for anticancer drug selection, drug combination assessment, biomarker detection, and drug mechanism research.

[ Treatment and Drug Screening ]

The use of 3D organoids allows for a more accurate observation of drug treatment effects than cells cultured on 2D plates.


Optimal Treatment Selection

Evaluation of the activation of various anticancer drugs using patient-derived 3D organoids to select the most effective treatment method.

Increased Accuracy

A combination of drugs is used in chemotherapy, rather than a single drug. To recreate this process, we combine various anticancer drugs to increase the accuracy of our treatment effectiveness assessment.

[ Stem Cell Therapy ]

Enhancing the fundamental cellular microenvironment by inducing self-organization and renewal through stem cell injection.


Mass Culture Technology

Mass-produced stem cells using 3D organoids are injected back into the patient to stimulate self-renewal.

Culture and Transplantation

Culture and transplantation of cells that comprise the microenvironment surrounding the stem cells to enhance cell growth within the organ.

Frequently Asked Questions

  • What is the difference between organoids and mini organs/artificial organs/clone organs?
    Mini organs are organ-like structures that are created through the use of organoid culture technology. On the other hand, artificial organs are manufactured organs that are created using animal organs or through bioengineering. Attis Lab has developed clone organs, which surpass the limitations that come along with the aforementioned technologies. Clone organs are created through the process of decellularization of organs and recellularization using patients’ own cells, which allows for immune response to be overcome, making this a breakthrough technology.
  • What does the microenvironment of the clone organ include?
    The extracellular matrix contains the differentiated cells, blood vessels, fibrous cells, and other necessary cellular elements necessary for proper organ function. When the implanted cells are able to self-organize and differentiate in a decellularized organ, it can be said that the organ microenvironment has properly been recreated.
  • Where are the organs used for decellularization/recellularization collected from?
    Organs from mini pigs, which are similar in size to human organs, are used. As decellularization removes all cells from the pig, the organ matrix becomes free of immune responses.
  • What are the uses of organoid technology?
    Organoid technology allows for the effective culture of all types of cells. It can have various useful applications, especially in basic stem cell research, drug development, and regenerative medicine.
  • Which organs will be decellularized?
    Any organ can be decellularized/recellularized, placing no limitations on this technology.
  • Will there be immune response issues during transplantation?
    Not only are immune-suppressed organs from mini-pigs are used, but as all existent cells are removed through decellularization and human cells are implanted, there are minimal immune response issues.
  • Can organoids be transplanted directly to humans?
    We are currently in the process of developing efficient human organoid transplantation methods.
  • What is the minimum sample amount necessary to culture a damaged organ or tissue?
    Even 1㎠ samples are enough to culture organoids of the given organ or tissue.
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